Episode 5- Dr Lloyd Steele: AI Reveals Hidden Immune Memory in Eczema & Psoriasis
Artificial intelligence is transforming how we understand human disease—but what happens when it uncovers biology that has remained hidden for more than a century?
In this upcoming episode, Prof Hashem Koohy is joined by Dr Lloyd Steele (Wellcome Sanger Institute & University of Cambridge) to discuss a landmark study that combines single-cell genomics, spatial transcriptomics, digital pathology, and AI-driven spatial analysis to construct one of the largest spatial atlases of human skin ever produced.
Together they explore how advanced computational approaches reveal previously hidden immune memory niches that may explain why inflammatory skin diseases such as eczema (atopic dermatitis) and psoriasis repeatedly return to the same locations, even after successful treatment.
In this episode, you’ll discover
Why conventional histopathology misses critical aspects of tissue biology.
How AI and spatial transcriptomics reveal hidden immune architecture.
The role of resident memory T cells in inflammatory relapse.
Newly discovered immune niches within sebaceous and sweat glands.
What atlas-scale biology means for precision medicine.
How computational immunology is reshaping dermatology and drug discovery.